Unravelling the Mechanism of TAK875 DILI
- 12 February 2021
- Resource Type: Posters, Toxicology & Safety
TAK-875 (fasiglifam) is a GPR40 agonist which was developed for the treatment of type 2 diabetes. However, TAK-875 was withdrawn from phase III clinical trials due to drug-induced liver injury (DILI).
In this poster, we focus on:
- investigating the mechanism behind the hepatotoxicity of TAK-875
- an in-depth understanding of the effect of TAK-875 on mitochondrial toxicity
- understanding the impact of plasma protein binding
Read our poster to learn more about our research!
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