Science Pool

Understanding the Mechanism behind Pilocarpine Neurotoxicity

Pilocarpine is a muscarinic cholinergic agonist which is used as an epilepsy model in rats. 

In this presentation, we evaluate:

  • the seizurogenic response of pilocarpine in vitro in different neuronal models including rat cortical neurons, rat hippocampal neurons and a human iPSC-derived co-culture model
  • the importance of maturation of the cells (DIV)
  • the use of MEA for the sensitive detection of firing, bursting and synchrony of the cells

View the presentation to learn more!

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