Understanding the Mechanism behind Pilocarpine Neurotoxicity
- 12 February 2021
- Resource Type: Presentations, Toxicology
Pilocarpine is a muscarinic cholinergic agonist which is used as an epilepsy model in rats.
In this presentation, we evaluate:
- the seizurogenic response of pilocarpine in vitro in different neuronal models including rat cortical neurons, rat hippocampal neurons and a human iPSC-derived co-culture model
- the importance of maturation of the cells (DIV)
- the use of MEA for the sensitive detection of firing, bursting and synchrony of the cells
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