Science Pool

The Role of Mitochondrial Toxicity in DILI Prediction

Drug-induced liver injury (often termed DILI) is a major cause of drug failure. The aetiology of DILI is often complex and multifactorial – meaning a single endpoint is unlikely to be sufficient in predicting this liability. Although 2D DILI models have traditionally been used in he prediction of DILI, the advantages of 3D models are now being realised.

In this poster, we focus on:

  • the use of multiparametric confocal high content screening (HCS) in DILI prediction
  • comparison of co-cultures of human liver 3D microtissues containing cryopreserved human hepatocytes with human non-parenchymal cells and HepaRG 3D spheroids
  • the assessment of a set of DILI-positive and DILI-negative compounds following drug exposure over 14 days
  • endpoints for DNA structure, GSH content, ROS formation and mitochondrial function

Read our poster to learn more about our research!

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