Science Pool

The Discovery and Structure-Activity Evaluation of (+)-Floyocidin B and Synthetic Analogs

The emergence of multidrug-resistant M. tuberculosis makes the discovery of novel anti-tuberculosis active structures an urgent priority. This collaborative scientific article shows that (+)-floyocidin B representing the first example of a novel dihydroisoquinoline class of fungus-derived natural products, displays promising antitubercular hit properties.