The Benefits of Stable Labelled Glutathione for Reactive Metabolite Screening

Reactive metabolites play a role in drug-induced toxicity. Early stage in vitro screening for electrophilic reactive metabolite formation involves the use of trapping agents such as glutathione (GSH) in the presence of a drug metabolising system.

In this poster, we focus on:

• the use of an alternative GSH trapping method using combined stable labelled GSH (GSH-¹³C₂,¹⁵N) with unlabelled GSH
• the advantages of the stable labelled GSH method over common approaches for the detection of GSH conjugation such as GSH neutral loss post acquisition
• analytical conditions including the HPLC and mass spectrometric methods 
• validation data for a set of literature compounds

Read our poster to learn more about our research!

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