Strategies to Minimise the Risk of DILI
- 7 March 2021
- Resource Type: Articles & Whitepapers, Toxicology & Safety
Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human in vitro cell-based models with multiparametric endpoints are now being developed to improve DILI prediction.
In this review article, we focus on:
- the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery
- how companies are addressing translational challenges using human relevant cell-based models
- a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2)
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