Screening for Drug-Induced Effects on Cholesterol Metabolism
The cytochrome P450 enzyme, CYP46A1, is predominantly expressed in the brain and plays a major role in cholesterol metabolism by converting cholesterol to 24-hydroxy cholesterol.
In this poster, we focus on:
- the development and validation of an in vitro high throughput screening platform for characterisation of inhibitors and activators of CYP46A1
- a comparison of testosterone with cholesterol as a potential replacement probe substrate for studying CYP46A1 metabolism
- data generated from a screening cascade of 2321 FDA approved drugs
Read our poster to learn more about our research!
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