Science Pool

Screening for Drug-Induced Effects on Cholesterol Metabolism

The cytochrome P450 enzyme, CYP46A1, is predominantly expressed in the brain and plays a major role in cholesterol metabolism by converting cholesterol to 24-hydroxy cholesterol.

In this poster, we focus on:

  • the development and validation of an in vitro high throughput screening platform for characterisation of inhibitors and activators of CYP46A1
  • a comparison of testosterone with cholesterol as a potential replacement probe substrate for studying CYP46A1 metabolism
  • data generated from a screening cascade of 2321 FDA approved drugs

Read our poster to learn more about our research!

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