Science Pool

Pharmacological Characterization of Mutant Huntingtin Aggregate-Directed PET Imaging Tracer Candidates

Huntington’s Disease is caused a mutation in the huntingtin (mHTT) gene which codes for the huntingtin (HTT) protein.

In this publication, we focus on:

  • a background to link between Huntington’s Disease and the mutant huntingtin gene (mHTT)
  • the development of PET tracers for imaging mHTT aggregates
  • characterisation of these PET tracers including pharmacological investigation of their binding affinities and selectivity