Huntington’s Disease is caused a mutation in the huntingtin (mHTT) gene which codes for the huntingtin (HTT) protein.
In this publication, we focus on:
- a background to link between Huntington’s Disease and the mutant huntingtin gene (mHTT)
- the development of PET tracers for imaging mHTT aggregates
- characterisation of these PET tracers including pharmacological investigation of their binding affinities and selectivity