Mutant huntingtin (mHTT) protein has been implicated in neuronal degeneration in Huntington’s Disease.
In this publication, we focus on:
- a background to the inherited neurodegenerative disorder, Huntington’s Disease, including the impact of the mutant huntingtin (mHTT) gene
- a discussion of the use of positron emission tomography (PET) to monitor disease progression
- the identification of a novel ligand CHDI-626 which binds to mHTT aggregates