Science Pool

PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates

Mutant huntingtin (mHTT) protein has been implicated in neuronal degeneration in Huntington’s Disease.

In this publication, we focus on:

  • a background to the inherited neurodegenerative disorder, Huntington’s Disease, including the impact of the mutant huntingtin (mHTT) gene
  • a discussion of the use of positron emission tomography (PET) to monitor disease progression
  • the identification of a novel ligand CHDI-626 which binds to mHTT aggregates