Science Pool

New Insights into Cardiotoxicity Prediction

Cardiotoxicity in response to pharmaceutical drugs, chemicals and environmental toxicants can develop as a result of changes in structural integrity of cardiac tissue or functional changes in cardiac electrophysiology. The development of new approach methodologies (NAMs) is important in predicting these cardiotoxic liabilities.

In this poster, we focus on:

  • the use of human iPSC-derived cardiomyocytes in combination with a panel of in vitro toxicology assays including:
    • calcium transient monitoring
    • high content imaging of morphological changes
    • cellular ATP assessment
    • high throughput transcriptomics using RNA-seq
  • the results from profiling 42 compounds in the assessment of structural and functional endpoints along with predictive outcome (sensitivity, specificity and accuracy)
  • mechanistic information including the detection of biological pathways associated with the cardiotoxic effects

Read our poster to learn more about our research!

Sounds interesting?
Enter your details below to continue reading…

By clicking on ‘Continue’ I agree that my data is being transferred to the Evotec Group. The Evotec Group currently consists of the following companies. For further details please see our Privacy Policy.

If you would like to be kept informed of our latest services, new research, events and other news please tick the box below:

Join our community

Discover the exclusive benefits on offer if you join our community.