Science Pool

Neural Activity of the Muscarinic Receptor Agonist Pilocarpine

Pilocarpine is a muscarinic receptor agonist which is used as a model inducer of epilepsy in the rat. We evaluated the seizurogenic response of pilocarpine using an in vitro MEA platform.

In this poster, we focus on:

  • a comparison of pilocarpine response in different neuronal cell types; cryopreserved rat cortical neurons, cryopreserved rat hippocampal neurons and a co-culture of human iPSC-derived glutamatergic neurons with astrocytes
  • the impact of DIV and cell maturation on the response
  • identifying muscarinic receptor expression over time

Read our poster to learn more about our research!

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