Science Pool

Multiparametric Human Liver Models for Predicting DILI

The benefits of 3D cell-based models in the prediction of drug-induced liver injury are now being realised. 

In this poster, we focus on:

  • the use of 3D models (cryopreserved human hepatocytes co-cultured with human non-parenchymal cells compared with HepaRG monocultures)
  • cytochrome P450 (CYP) activity in the different models
  • HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
  • prediction of DILI potential for a set of DILI-positive and negative compounds

Read our poster to learn more about our research!

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