Mitobiogenesis – A Key Mechanism in Drug-Induced Toxicity
- 12 February 2021
- Resource Type: Presentations, Toxicology
Mitobiogenesis (or mitochondrial biogenesis) is defined as the growth and division of pre-existing mitochondria. Drug-induced perturbations in this process can result in mitochondrial dysfunction or toxicity.
In this presentation, we focus on:
- mechanisms involved in mitochondrial toxicity including drug-induced mitobiogenesis
- the development of a high throughput high content imaging assay for detecting drug-induced effects on mitobiogenesis
- validation of the assay using known drugs which inhibit mitochondrial DNA and protein synthesis (e.g., antibiotics, anti-viral and anticancer drugs) as well as some non-mitochondrial toxicants.
View the presentation to learn more!
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