Science Pool

Mitobiogenesis – A Key Mechanism in Drug-Induced Toxicity

Mitobiogenesis (or mitochondrial biogenesis) is defined as the growth and division of pre-existing mitochondria. Drug-induced perturbations in this process can result in mitochondrial dysfunction or toxicity. 

In this presentation, we focus on:

  • mechanisms involved in mitochondrial toxicity including drug-induced mitobiogenesis
  • the development of a high throughput high content imaging assay for detecting drug-induced effects on mitobiogenesis
  • validation of the assay using known drugs which inhibit mitochondrial DNA and protein synthesis (e.g., antibiotics, anti-viral and anticancer drugs) as well as some non-mitochondrial toxicants.

View the presentation to learn more!

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