The mitochondria are a common target of drug-induced toxicity. A number of approaches are used to detect mitochondrial toxicity but how do we know which to use?
In this poster, we focus on:
a comparison of the different methods including the glucose/galactose (glu/gal) cytotoxicity assay, high content screening (HCS) method for mitochondrial membrane potential and cytotoxicity, and the Seahorse flux analyser
the ability of the different methods to predict mitochondrial toxicity through sensitivity, specificity and accuracy assessment
an insight into the mechanism of mitochondrial toxicity through the Seahorse flux analyser and permeabilised cell assay.
Read our poster to learn more about our research!
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