Science Pool

Mechanisms of Mitochondrial Toxicity – An In-depth Analysis using In Vitro Assays

The mitochondria are a common target of drug-induced toxicity. A number of approaches are used to detect mitochondrial toxicity but how do we know which to use?

In this poster, we focus on:

  • a comparison of the different methods including the glucose/galactose (glu/gal) cytotoxicity assay, high content screening (HCS) method for mitochondrial membrane potential and cytotoxicity, and the Seahorse flux analyser
  • the ability of the different methods to predict mitochondrial toxicity through sensitivity, specificity and accuracy assessment
  • an insight into the mechanism of mitochondrial toxicity through the Seahorse flux analyser and permeabilised cell assay.

Read our poster to learn more about our research!

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