Science Pool

Mechanisms of Drug-induced Toxicity Guide

Our popular, easy-to-follow guide: ‘Mechanisms of Drug-induced Toxicity’ is available to read online.

Read about:

  • an overview of the different mechanisms of toxicity including:
    • mitochondrial toxicity
    • reactive oxygen species (ROS) and oxidative stress
    • reactive metabolite formation
    • cell cycle mediated toxicity
    • apoptosis
    • genotoxic and non-genotoxic carcinogens
    • phospholipidosis
    • steatosis
    • cholestasis
    • cardiac ion channel effects and hypertrophy
  • an assessment of the current in vitro methods available for determining mechanistic toxicology 
  • key references and further reading related to the topic

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