Science Pool

In Vitro 3D Heart – Microtissue Model for Understanding Cardiotoxicity

In vitro 3D microtissue models are transforming our understanding of cardiotoxicity.

In this poster, we focus on:

  • the use of a 3D cardiac triculture model consisting of iPSC-derived cardiomyocytes, cardiovascular endothelial cells and cardiac fibroblasts in cardiotoxicity prediction
  • the detection of functional and structural mechanisms of cardiotoxicity
  • calcium flux as a sensitive detection method for cardiac contraction as well as microtissue area for identifying cardiac hypertrophy
  • HCS detection of cell health markers such as mitochondrial function, calcium homeostasis and nuclei/DNA structure

Read our poster to learn more about our research!

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