Science Pool

HµREL Co-Culture Model for Low Clearance

Incubation times for in vitro hepatocyte stability assays are usually relatively short in order to maintain cell viability and enzymatic activity. This can limit the accuracy of clearance prediction for stable compounds. 

In this poster, we focus on:

  • a comparison of three human models of in vitro clearance; the HμREL coculture model, 2D hepatocyte monoculture model and suspension hepatocyte model 
  • data were scaled to predict in vivo human clearance
  • the suitability of each system to accurately predict the clearance of stable compounds was assessed

Read our poster to learn more about our research!

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