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Fighting Tuberculosis by Targeting the Essential Enzyme 4’-Phosphopantetheinyl Transferase (PptT)

4’-Phosphopantetheinyl transferase (PptT) is a crucial enzyme for the survival and virulence of Mycobacterium tuberculosis (Mtb), making it an attractive target for tuberculosis treatment. In recent research, our collaborators at University of North Carolina (UNC ); Weill Cornell Medical College, Texas Agricultural and Mechanical University (TAMU) explored ways to replace the amidinourea moiety in the previously known PptT inhibitor AU 8918.  These findings hold promise for developing new drugs to combat mycobacterial infections.

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