Science Pool

Evaluating Pharmacology and Neurotoxicity using MEA

Advances in human iPSC-derived neuronal models in conjunction with microelectrode array (MEA) technology has enhanced our understanding of complex burst organisation and network characteristics in humans. This now provides a viable human model for studying drug-induced toxicity and CNS liabilities as well as potential pharmacology effects on the neurones.

In this poster, we focus on:

  • investigating co-cultures of human iPSC-derived glutamatergic neurons with astrocytes on the MEA platform
  • determining spike activity, burst organisation and network organisation (synchrony) patterns for different types of CNS compounds (GABAA agonists, potassium channel blockers, opioid receptor agonist, glycine receptor antagonist and cholinergic and muscarinic receptor agonists)
  • understanding developmental and pharmacological responses when assessed by MEA

Read our poster to learn more about our research!

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