Dual Detection of Functional and Structural Cardiotoxicity
- 16 June 2021
- Resource Type: IND Enabling Studies/Preclinical Development, Posters, Toxicology & Safety
Cardiotoxic drugs can display acute alteration in the mechanical function of the myocardium (functional changes) or morphological damage to cardiomyocytes and/or loss of viability (structural changes).
In this poster, we focus on:
- the detection of functional cardiomyocyte changes through monitoring of calcium transients using human iPSC-derived cardiomyocytes
- the analysis of structural morphology using high content imaging (calcium homeostasis and mitochondrial function) as well as cellular ATP in human iPSC-derived cardiomyocytes
- the presentation of a strategy for understanding cardiotoxicity risk for novel compounds enabling in vitro to in vivo translation at an early stage in preclinical screening.
Read our poster to learn more about our research!
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