In vitro 3D cell-based models are more representative of the complex in vivo microenvironment than traditional 2D monolayers. Furthermore, these models allow for long term compound exposures – more closely replicating clinical dosing strategies.
In this poster, we focus on:
3D human liver microtissues formed from multiple donors co-cultured with human non-parenchymal cells
exposure of the cells to multiple doses of hepatotoxins and non-hepatotoxins
HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
the impact of correcting for therapeutically relevant tissue Cmax
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