DILI Prediction using Human 3D Models, HCS and Concentration Normalisation
- 11 February 2021
- Resource Type: Posters, Toxicology & Safety
In vitro 3D cell-based models are more representative of the complex in vivo microenvironment than traditional 2D monolayers. Furthermore, these models allow for long term compound exposures – more closely replicating clinical dosing strategies.
In this poster, we focus on:
- 3D human liver microtissues formed from multiple donors co-cultured with human non-parenchymal cells
- exposure of the cells to multiple doses of hepatotoxins and non-hepatotoxins
- HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
- the impact of correcting for therapeutically relevant tissue Cmax
Read our poster to learn more about our research!
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