Full poster title: Development of recombinase-based targeted integration systems for production of exogenous proteins using transposon-mediated landing pads
Summary of the poster:
- We demonstrated proof of principle of targeted integration systems in our CHO host cell line with consistent genome integration into expected landing pad sites
- Test cases using three antibody or antibody-fusion therapeutic molecules showed similar levels of productivity
- We also show preliminary data from ongoing work to build upon these targeted integration systems, which includes isolating a single-copy landing pad cell line and developing a CHO display platform
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