Science Pool

Development of Recombinase-Based Targeted Integration Systems

Full poster title: Development of recombinase-based targeted integration systems for production of exogenous proteins using transposon-mediated landing pads

Summary of the poster:

  • We demonstrated proof of principle of targeted integration systems in our CHO host cell line with consistent genome integration into expected landing pad sites
  • Test cases using three antibody or antibody-fusion therapeutic molecules showed similar levels of productivity
  • We also show preliminary data from ongoing work to build upon these targeted integration systems, which includes isolating a single-copy landing pad cell line and developing a CHO display platform

Read our poster to learn more about our research!