Development of Potential PET Ligand for Imaging Mutant Huntingtin Aggregates

Mutant huntingtin (mHTT) forms protein aggregates characteristic of Huntington’s Disease pathology.

In this publication, we focus on:

• a background to Huntington’s Disease including the mutant huntingtin gene (mHTT)
• a discussion of the benefits of sensitive biomarkers to monitor disease progression
• the discovery of an mHTT aggregate-specific PET ligand suitable for live brain imaging

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