Science Pool

Development of Potential PET Ligand for Imaging Mutant Huntingtin Aggregates

Mutant huntingtin (mHTT) forms protein aggregates characteristic of Huntington’s Disease pathology.

In this publication, we focus on:

  • a background to Huntington’s Disease including the mutant huntingtin gene (mHTT)
  • a discussion of the benefits of sensitive biomarkers to monitor disease progression
  • the discovery of an mHTT aggregate-specific PET ligand suitable for live brain imaging