Science Pool

Development of a Ligand for In Vivo Imaging of Mutant Huntingtin in Huntington’s Disease

Huntington´s Disease (HD) is a hereditary neurodegenerative disorder that is caused by a mutation in the huntingtin gene (mHTT) leading to deposition of pathologic protein aggregates in the brain.

This paper focuses on:

  • Visualization of mHTT aggregate expression by positron emission tomography (PET) in rodent HD model
  • Utility of the previously described novel PET imaging ligand CHDI-180 for detection of mHTT in rodent and post-mortem human HD brain
  • Ability of CHDI-180 to serve as functional response indicator for mHTT lowering therapies