Huntington´s Disease (HD) is a hereditary neurodegenerative disorder that is caused by a mutation in the huntingtin gene (mHTT) leading to deposition of pathologic protein aggregates in the brain.
This paper focuses on:
- Visualization of mHTT aggregate expression by positron emission tomography (PET) in rodent HD model
- Utility of the previously described novel PET imaging ligand CHDI-180 for detection of mHTT in rodent and post-mortem human HD brain
- Ability of CHDI-180 to serve as functional response indicator for mHTT lowering therapies
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