Science Pool

Determining Chromatographic Hydrophobicity Index using LC-TOF

Lipophilicity is an essential physicochemical property used to predict compound behaviour with respect to pharmacokinetics, pharmacodynamics and safety. 

In this poster, we focus on:

  • the use of the chromatographic hydropobicity index (CHI) as an alternative to LogD for lipophilicity determination
  • the use of LC Time-of-Flight mass spectrometry for CHI determination and its advantages with respect to reduced inference from impurities, decreased compound requirements and improved throughput
  • applicability of CHI for large scale screening projects
  • the presentation of the reproducibility and robustness of the method along with comparison with literature values

Read our poster to learn more about our research!

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