Detecting Cardiotoxicity of Chronically Exposed Drugs using MEA
- 12 February 2021
- Resource Type: Presentations, Toxicology
Cardiotoxicity is a key cause of late stage attrition in drug development. iPSC-derived cardiomyocytes remain viable for more than 2 weeks on MEA plates. As MEA measures electrical activity without addition of any reagents, the cells can be exposed and monitored over extended time periods.
In this presentation, we focus on:
- a background to MEA
- design of the assay for detecting cardiotoxicity following chronic exposure to drugs
- case studies for cardiotoxic drugs with different mechanisms (hERG traffickers, multichannel blockers, specific ion channel effects)
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