Science Pool

Detecting BMS-986094 Cardiotoxicity using Chronic Multiplatform Assay

BMS-986094 (INX-08189) is a prodrug of a guanosine nucleotide analogue which was developed to treat hepatitis C virus but was discontinued during clinical trials due to cardiotoxic effects.

In this poster, we focus on:

  • the mechanism of BMS-986094 cardiotoxicity 
  • the impact of chronic dosing over multiple time points
  • evaluation of data from an MEA platform, a cardiac mitochondrial protein biogenesis assay, a calcium flux assay and a cardiac cytotoxicity assay 

Read our poster to learn more about our research!

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