“Corramycin is a novel zwitterionic peptide with antibiotic properties. However, being mainly active against E. coli, Corramycin interest as a starting point for a new antibacterial program was challenging despite a promising activity in an E. coli septicemia/peritonitis animal model. We postulated that Corramycin spectrum could be improved if bacterial penetration could be enhanced.
In this poster we:
This chemical program of >800 derivatives synthesized showed the benefits of vectorization to enlarge spectrum and to improve potency of modestly active antibacterials, as well as the need of a careful molecular design to solve issues such as the resistance risk and metabolic instability.
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