Comparison of MEA and Neurite Outgrowth for Determining CNS Liability
- 12 February 2021
- Resource Type: Posters, Toxicology & Safety
Domoic acid is a neurotoxin which was associated with the poisoning of 107 people and 3 subsequent deaths on Prince Edward Island in 1987 following the ingestion of mussels containing this poison. The associated neurotoxic effects of domoic acid are clearly identified at concentrations of ≥ 1µM using neurons analysed on a microelectrode array (MEA) platform. Interestingly, domoic acid had no effect up to 25µM in the neurite outgrowth assay (another common method for detecting neurotoxicity).
In this poster, we focus on:
- a comparison of the neurite outgrowth assay with the MEA platform
- sensitivity of the two methods for detecting neurotoxins and seizurogenic compounds
- a screening strategy for testing neurotoxic compounds
Read our poster to learn more about our research!
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