Science Pool

Comparing In Vitro Mitochondrial Toxicity Assays

Mitochondria are a common target for drug-induced toxicity. Several different in vitro methods exist for investigating drug-induced mitochondrial toxicity. 

In this poster, we focus on:

  • a comparison of three different in vitro assays for detecting mitochondrial toxicity (Glu/Gal cytotoxicity assay, Seahorse Flux Analyser and high content imaging of mitochondrial membrane potential)
  • the effect of protein binding on the mitochondrial toxicity
  • recommendations for a tiered screening approach

Read our poster to learn more about our research!

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