Science Pool

Choosing the Optimal Model for In Vitro Neurotoxicity Assessment

As the CNS is a complex organ system, neurotoxicity can be difficult to assess and detect during preclinical development in animal models.

In this poster, we focus on:

  • the use of cell-based models in conjunction with MEA to identify neurogenic and seizurogenic compounds
  • a comparison between rat cortical neurons and a co-culture of human iPSC-derived glutamatergic neurons with iPSC-derived astrocytes in their response to known neurotoxic and seizurogenic compounds  
  • a recommended in vitro screening approach for early detection of neurotoxicity

Read our poster to learn more about our research!

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