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![Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity](https://sciencepool.evotec.com/wp-content/uploads/elementor/thumbs/shutterstock_1306602358-neuron-pink-03-science-pool-scaled-pvurfvgm6n2r25d7orsntmig5tvj8z32ocydfuvskc.jpg "Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity")