Science Pool

Application of a Low Intrinsic Clearance Assay in Drug Discovery

In order to accurately predict human pharmacokinetics and efficacious dose, a robust measurements of clearance is essential.

In this poster, we focus on:

  • a novel primary human hepatocyte media supplement (HepExtendTM)
  • a comparison of HepExtendTM with the widely used CM4000 with and without a Geltrex overlay
  • a correlation of scaled in vitro human intrinsic clearance with in vivo human intrinsic clearance

Read our poster to learn more about our research!

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