Application of a Low Intrinsic Clearance Assay in Drug Discovery

In order to accurately predict human pharmacokinetics and efficacious dose, a robust measurements of clearance is essential.

In this poster, we focus on:

• a novel primary human hepatocyte media supplement (HepExtend^TM)
• a comparison of HepExtend^TM with the widely used CM4000 with and without a Geltrex overlay
• a correlation of scaled in vitro human intrinsic clearance with in vivo human intrinsic clearance

Read our poster to learn more about our research!

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