Science Pool

Addressing the Challenges of Non-Specific Binding in a HT-ADME Environment

During analysis of samples from HT-ADME screening, non-specific binding can cause challenges due to accumulation within the analytical system. This can result in poor peak shape, low sensitivity, increasing back pressure/pressure spikes, carryover or system clogging.  

In this poster, we focus on:

  • the evaluation of the WatersTM Acquity Premier UPLC in conjunction with the Acquity Premier HSS T3 column technology which contain an inert coating specifically formulated to eliminate analyte/surface interactions
  • a comparison with standard UPLC technology
  • details on the benefits of using the Waters AcquityTM system in terms of chromatographic performance and sensitivity

Read our poster to learn more about our research!

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